J Pathol Transl Med.  2015 Jan;49(1):1-4. 10.4132/jptm.2014.11.17.

TdT+ T-Lymphoblastic Proliferation in Castleman Disease

• Woo CG
• Huh J

• KMID: 2381346
• DOI: http://doi.org/10.4132/jptm.2014.11.17

Abstract

No abstract available.

MeSH Terms

Giant Lymph Node Hyperplasia*

Figure

• 

  Fig. 1. Hyaline vascular-type Castleman disease. (A) Abdominal computed tomography demonstrates a well-defined homogeneous enhancing mass (arrow) in the retroperitoneum. (B) The mass exhibits a fleshy cut surface with central fibrosis. (C) Variably-sized follicles with multiple germinal centers are present. The interfollicular compartment is expanded with vascular proliferation. (D) Follicular structures appear smaller due to the regression of germinal centers. (E) Mantle zone lymphocytes have a laminated appearance, similar to onion skin. The vessel penetrating the atrophic follicle has a lollipop-like appearance. (F) Hyperplastic follicular dendritic cells are stained with CD21.

• 

  Fig. 2. Indolent T-lymphoblastic proliferation (iTLBP). (A) Nodular and diffuse areas of monotonous lymphoid cell infiltration in the interfollicular and perifollicular regions. (B) The cells show blastic nuclei with open chromatin and inconspicuous nuclei. (C–F) Cells are immunopositive for CD3 (C), terminal deoxynucleotidyl transferase (D), and CD33 (E), and have an increased Ki-67 labeling index (F). (G) Polymerase chain reaction study of the T-cell receptor gamma genes using BIOMED-2 primers shows no evidence of monoclonality.

Reference

1. Velankar MM, Nathwani BN, Schlutz MJ, et al. Indolent T-lymphoblastic proliferation: report of a case with a 16-year course without cytotoxic therapy. Am J Surg Pathol. 1999; 23:977–81.

2. Ohgami RS, Arber DA, Zehnder JL, Natkunam Y, Warnke RA. Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma. Adv Anat Pathol. 2013; 20:137–40.

3. Ohgami RS, Zhao S, Ohgami JK, et al. TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2012; 36:1619–28.

4. Qian YW, Weissmann D, Goodell L, August D, Strair R. Indolent T-lymphoblastic proliferation in Castleman lymphadenopathy. Leuk Lymphoma. 2009; 50:306–8.

5. Ohgami RS, Sendamarai AK, Atwater SK, et al. Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression. Am J Surg Pathol. 2014; 38:1298–304.