Epidemiol Health.  2015;37:e2015052. 10.4178/epih/e2015052.

Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis

• Bae JM
• Kim EH

• KMID: 2380689
• DOI: http://doi.org/10.4178/epih/e2015052

Abstract

OBJECTIVES
The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW.
METHODS
Based on a prior SR and some expert reviews, we identified refereed, cited, or related articles using the PubMed and Scopus databases. All case-control studies that reported the odds ratio of HPV infection in LCNSW were selected. An estimate of the summary odds ratio (SOR) with 95% confidence intervals (CI) was calculated.
RESULTS
A total of four case-control studies were included. The fixed-effect model was applied because of homogeneity (I-squared=0.0%). The SORs in women and in never-smokers were 5.32 (95% CI, 1.75 to 16.17) and 4.78 (2.25 to 10.15) respectively.
CONCLUSIONS
These results showed a significant effect of HPV infection in LCNSW. It is evident that developing a preventive plan against LCNSW may be necessary.

Keyword

Lung neoplasms; Risk factor; Human papillomavirus; Meta-analysis

MeSH Terms

Case-Control Studies
Female
Humans*
Incidence
Lung Neoplasms*
Lung*
Male
Odds Ratio
Papillomavirus Infections*
Risk Factors