Epidemiol Health.  2011;33:e2011007.

Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population

Affiliations
  • 1Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. jsunha@yuhs.ac
  • 2Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
  • 3Department of Food and Nutrition and Research Institute of Obesity Sciences, Sungshin Women's University, Seoul, Korea.
  • 4Division of Cardiology, Department of Internal Medicine, Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown.
METHODS
The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis.
RESULTS
WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women.
CONCLUSION
These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.

Keyword

Adiponectin; Diabetes; Impaired fasting glucose; Insulin resistance

MeSH Terms

Adiponectin
Fasting
Female
Glucose
Homeostasis
Humans
Insulin Resistance
Logistic Models
Male
Odds Ratio
Waist Circumference
Adiponectin
Glucose
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