Korean J Blood Transfus.
2017 Apr;28(1):77-81. 10.17945/kjbt.2017.28.1.77.
Anti-LW Showing Anti-D Mimicking Specificity: A Case Report
- Affiliations
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- 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. duck.cho@skku.edu
- KMID: 2379726
- DOI: http://doi.org/10.17945/kjbt.2017.28.1.77
Abstract
- LW antigens are expressed in higher intensities in D-positive blood cells than D-negative cells, which can result in false identification of anti-D in pretransfusion testing. Although several cases of anti-LW have been reported abroad, to the best of our knowledge, none have been reported in Korea. Herein, we report a case of anti-LW in a 58 year-old RhD positive patient with non-Hodgkin's lymphoma with a positive direct Coombs test and a suspicion of the presence of passive anti-D antibodies because of a history of intravenous immunoglobulin administration. However, during a 5-month follow up, the antibody was confirmed as anti-LW on grounds that it showed weakened reaction in dithiothreitol treated cells and enforced reaction in cord O+ cells when compared to the results from antibody identification panel cells.
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