Korean J Anesthesiol.  2016 Oct;69(5):453-459. 10.4097/kjae.2016.69.5.453.

Effective doses of cisatracurium in the adult and the elderly

• Kim JH
• Lee YC
• Lee SI
• Park SY
• Choi SR
• Lee JH
• Chung CJ
• Lee SC

• KMID: 2379234
• DOI: http://doi.org/10.4097/kjae.2016.69.5.453

Abstract

BACKGROUND
There are few information about the differences of the effective dose (ED) of cisatracurium between the adult and the elderly. We investigated the ED and the onset time of cisatracurium in the adults and the elderly.
METHODS
We studied two hundred patients of the adults aged 20 through 64 years and the elderly aged ≥ 65 years, with American Society of Anesthesiologists physical status I or II. Each 100 patients with 20 patients of each dose group, randomly selected from 30, 40, 50, 60 or 70 µg/kg of cisatracurium, were randomly allocated to the adults and the elderly groups. We recorded the 0.1 Hz single twitch responses of the adductor pollicis and the onset times to maximal blockade. The magnitude of muscle relaxation was recorded by using an acceleromyography. The effect of cisatracurium on single twitch was calculated as percent reduction. After converting each drug dose into logarithm and percent reduction of the muscle reduction into probit, the EDs representing the muscle relaxation effects of 5%, 25%, 50%, 75% and 95% were estimated using the linear regression analysis.
RESULTS
No significant differences were found in age, weight, height, or body mass index within or between the groups. The EDâ‚…â‚€ and ED₉₅ of the adult group were 35.39 and 59.58 µg/kg. The EDâ‚…â‚€ and ED₉₅ of the elderly group were 34.89 and 55.50 µg/kg, respectively. The onset times were 375.4 ± 76.9 seconds in the adult group and 369.1 ± 70.0 seconds in the elderly group.
CONCLUSIONS
The ED and the onset time were not significantly different between the adult and the elderly.

Keyword

Aged; Cisatracurium

MeSH Terms

Adult*
Aged*
Body Mass Index
Humans
Linear Models
Muscle Relaxation