Psychiatry Investig.  2017 May;14(3):380-382. 10.4306/pi.2017.14.3.380.

Tardive Dystonia Related with Aripiprazole

• Kim S
• Lee SY
• Kim M
• Lee KU

• KMID: 2378656
• DOI: http://doi.org/10.4306/pi.2017.14.3.380

Abstract

Tardive dystonia is characterized by sustained, generally slow involuntary twisting movements. It is estimated to occur at a frequency of 1% to 4% among patients who are taking an antipsychotic agent. Unlike the first generation antipsychotics, the second generation antipsychotics are less likely to cause neuroleptic-induced movement disorder. For aripiprazole, only a few cases have been reported for tardive dystonia. We present a young male, who developed a severe tardive dystonia after taking aripiprazole for 5 years. The patient was admitted to for the treatment of both hisdystonic and psychotic symptoms. Olanzapine was administered instead of aripiprazole and while his psychotic symptoms improved, the dystonic symptoms were continued. Therefore, olanzapine was switched to clozapine while augmenting with benzodiazepine, anti-cholinergic, and ginko biloba to control his tardive dystonia. After 2 weeks of treatment, the dystonic movement decreased remarkably.

Keyword

Aripiprazole; Clozapine; Tardive dystonia; Schizoaffective disorder; Ginkgo biloba

MeSH Terms

Antipsychotic Agents
Aripiprazole*
Benzodiazepines
Clozapine
Ginkgo biloba
Humans
Male
Movement Disorders*
Psychotic Disorders
Antipsychotic Agents
Aripiprazole
Benzodiazepines
Clozapine