Ann Dermatol.  2017 Jun;29(3):365-367. 10.5021/ad.2017.29.3.365.

Dermoscopy as a Supportive Instrument in the Early Recognition of Erosive Adenomatosis of the Nipple and Mammary Paget's Disease

• Errichetti E
• Avellini C
• Pegolo E
• De Francesco V

• KMID: 2378545
• DOI: http://doi.org/10.5021/ad.2017.29.3.365

Abstract

No abstract available.

MeSH Terms

Dermoscopy*
Nipples*
Paget's Disease, Mammary*

Figure

• 

  Fig. 1 Clinical examination of the right nipple shows a slight erosion (arrow) associated with moderate hyperkeratosis in the first patient (A) and a small serohematic crust (arrow) in the second patient (B). Dermoscopic examination (carried out with DermLite DL3×10; 3Gen, San Juan Capistrano, CA, USA) of the right nipple in the first case displays whitish/yellowish hyperkeratosis and some dotted vessels (circles) on a reddish-whitish background (C), while it shows a brownish-reddish crust associated with linear irregular vessels (circles) on a pinkish-whitish background in the second case (D). Histologic examination in the first patient reveals typical features of erosive adenomatosis of the nipple, namely ductal structures in the dermis focally connected to the overlying epidermis (H&E, ×40); these ducts result mostly lined with a basal layer made up of myoepithelial cells and a luminal layer of epithelial cells exhibiting apocrine differentiation (box) (H&E, ×200) (E). In the second patient, histology shows large atypical cells with hyperchromatic eccentric nuclei and abundant cytoplasm throughout the epidermis, hyperkeratosis, parakeratosis, and acanthosis (H&E, ×200); immunohistochemical analysis demonstrates that the tumour cells are positive for cytokeratin 7 (box) (F). All these findings are consistent with the diagnosis of Paget's disease.

Reference

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