Korean Circ J.  2017 Mar;47(2):238-244. 10.4070/kcj.2016.0351.

Association Between Interleukin-18 Level and Left Ventricular Mass Index in Hypertensive Patients

Affiliations
  • 1Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
  • 2Department of Cardiology, Bakent University Hospital, Ankara, Turkey. suleymanozbicer@gmail.com

Abstract

BACKGROUND AND OBJECTIVES
In clinical trials, hypertensive patients tend to have higher interleukin-18 (IL-18) concentrations than normotensive groups, but the relationship between IL-18 and left ventricular hypertrophy (LVH), which is a marker of end-organ damage, is not well studied. We aimed to investigate the relationship between IL-18 and LVH in apparently healthy subjects free of clinically significant atherosclerotic disease.
SUBJECTS AND METHODS
We enrolled 198 subjects (102 women and 96 men) between May 2006 and March 2007, who were free of cardiovascular or immune diseases, but were suspected to have hypertension. Twenty-four-hour ambulatory blood pressure monitoring and two-dimensional echocardiography were performed. Lipid profiles, high-sensitivity CRP (hs-CRP), IL-18, and whole blood cell counts were measured for all subjects.
RESULTS
White blood cell count, hs-CRP, left ventricular mass, left ventricular mass index (LVMI), and IL-18 were higher in the hypertensive group than in the normotensive group (p=0.045, p=0.004, p<0.0001, p=0.001, and p=0.017 respectively). Twenty-four hour day and night systolic and diastolic blood pressure averages were positively correlated with IL-18 level in the entire study population. In multivariate regression analysis, left ventricular mass index and hs-CRP level were independently associated with IL-18 level in both the hypertensive group and the entire study population (β=0.154, β=0.149 p=0.033, p=0.040 and β=0.151, β=0.155 p=0.036, p=0.032 respectively)
CONCLUSION
We found that IL-18 level independently predicted LVMI in both the general population and in newly diagnosed hypertensive patients.

Keyword

Interleukin-18; Inflammation; Hypertension; Left ventricular hypertrophy

MeSH Terms

Blood Cell Count
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Echocardiography
Female
Healthy Volunteers
Humans
Hypertension
Hypertrophy, Left Ventricular
Immune System Diseases
Inflammation
Interleukin-18*
Leukocyte Count
Interleukin-18

Figure

  • Fig. 1 Correlation between interleukin-18 and 24-hour systolic blood pressure. BP: blood pressure.

  • Fig. 2 Correlation between interleukin-18 and left ventricular mass index.


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