Korean Circ J.  2017 Mar;47(2):168-170. 10.4070/kcj.2016.0401.

Mitochondrial Metabolic Inhibition and Cardioprotection

• Lee SR
• Han J

• KMID: 2377453
• DOI: http://doi.org/10.4070/kcj.2016.0401

Abstract

No abstract available.

MeSH Terms

Mitochondria, Heart
Gasotransmitters
Adenosine Diphosphate
Myocardial Reperfusion Injury
Cardiotonic Agents
Electron Transport Complex IV
Gasotransmitters
Adenosine Diphosphate
Cardiotonic Agents
Electron Transport Complex IV

Figure

• 

  Fig. 1 Inhibition of mitochondrial complexes involved in cardioprotection. I–V indicate respective mitochondrial complexes. NADH: reduced nicotinamide adenine dinucleotide, NAD+: oxidized nicotinamide adenine dinucleotide, ADP: adenosine diphosphate, Pi: inorganic phosphate, ATP: adenosine triphosphate, ΔΨm: mitochondrial membrane potential, IPC: ischemic preconditioning, Cyt C: cytochrome C, FCCP: carbonyl cyanide-p-trifluoromethoxyph enylhydrazone, DNP: dinitrophenol, SOD: superoxide dismutase, GPx: glutathione peroxidase.

Reference

1. Hausenloy DJ, Barrabes JA, Botker HE, et al. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Res Cardiol. 2016; 111:70.

2. Chen Q, Camara AK, Stowe DF, Hoppel CL, Lesnefsky EJ. Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion. Am J Physiol Cell Physiol. 2007; 292:C137–C147.

3. Burwell LS, Nadtochiy SM, Brookes PS. Cardioprotection by metabolic shut-down and gradual wake-up. J Mol Cell Cardiol. 2009; 46:804–810.

4. Srinivasan S, Avadhani NG. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med. 2012; 53:1252–1263.

5. Cebová M, Košútová M, Pecháňová O. Cardiovascular effects of gasotransmitter donors. Physiol Res. 2016; 65:Supplementum 3. S291–S307.

6. Yang Z, Lin L. Inhibiting cytochrome c oxidase leads ti allevated ischemia reperfusion injury. Korean Circ J. 2017; 47:193–200.

7. Heusch G, Rassaf T. Time to give up on cardioprotection? A critical appraisal of clinical studies on ischemic pre-, post-, and remote conditioning. Circ Res. 2016; 119:676–695.

8. Hüttemann M, Helling S, Sanderson TH, et al. Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim Biophys Acta. 2012; 1817:598–609.