Korean J Anesthesiol.  2017 Apr;70(2):213-216. 10.4097/kjae.2017.70.2.213.

Decrease in spectral entropy by low tidal volume ventilation-associated severe hypercapnia: a case report

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Yeungnam University School of Medicine, Daegu, Korea. applejsm@gmail.com

Abstract

Severe hypercapnia can be predicted by a decrease in cerebral electrical activity. The authors describe a sudden decrease in spectral entropy due to severe hypercapnia-induced respiratory acidosis in a patient with chronic pulmonary obstructive disease during lung resection. After two and a half hours of low tidal volume ventilation in the lateral position, the state entropy suddenly dropped from 45 to 7, without any changes in the effect-site concentration of propofol, end-tidal carbon dioxide (COâ‚‚) tension, oxygen saturation, or arterial pressure. However, arterial blood gas analysis showed severe respiratory acidosis (pH 7.01, PaCOâ‚‚ 115 mmHg and PaOâ‚‚ 246 mmHg with FIOâ‚‚ of 0.5). Immediate hyperventilation improved the state entropy and acid-base balance. Electroencephalography-based spectral entropy can detect severe hypercapnia in chronic pulmonary obstructive disease patients with a large arterial to end-tidal CO2 difference due to prolonged hypoventilation during thoracic surgery.

Keyword

Electroencephalography; Entropy; Hypercapnia; Hypoventilation

MeSH Terms

Acid-Base Equilibrium
Acidosis, Respiratory
Arterial Pressure
Blood Gas Analysis
Carbon Dioxide
Electroencephalography
Entropy*
Humans
Hypercapnia*
Hyperventilation
Hypoventilation
Lung
Oxygen
Propofol
Thoracic Surgery
Tidal Volume*
Ventilation
Carbon Dioxide
Oxygen
Propofol
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