Korean J Endocr Surg.  2009 Jun;9(2):85-89. 10.16956/kjes.2009.9.2.85.

Bilaterality of Papillary Thyroid Carcinoma: Analysis of Clinicopathologic Factors and the Value of Preoperative Ultrasonography

• Lee HS
• Kwak BS
• Kim YD
• Kim HY
• Park YJ
• Baik YH
• Oh MG
• Choi WY

• KMID: 2375751
• DOI: http://doi.org/10.16956/kjes.2009.9.2.85

Abstract

PURPOSE
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. The extent of the initial surgical treatment for PTC is still controversial and the bilaterality of PTC is an important factor for determining the extent of surgical resection. The aim of this study was to analyze clinicopathologic factors and the value of preoperative ultrasonography (PU) for bilateral tumor.
METHODS
We retrospectively reviewed clinicopathologic factors and PU findings of 91 patients who underwent total thyroidectomy for PTC at the Dongguk University Ilsan Hospital from January 2006 to April 2009.
RESULTS
Of the 91 patients, 28 (30.7%) had bilateral PTC in postoperative pathology. Of these 28 patients, only 18 patients (64.3%) were checked for bilateral PTC by PU findings and fine needle aspiration cytology. Sensitivity and specificity for bilaterality of PTC were 64.3% and 85.7%, respectively. The presence of benign nodules or malignant nodules in the same lobe in PU (P=0.008) and post-operative pathology (P=0.014) were statistically correlated with bilaterality.
CONCLUSION
For the surgical care of PTC, bilaterality must always be considered, even though the tumor is diagnosed unilateral small PTC. PU in PTC patients has limited diagnostic value for bilateral PTC.

Keyword

Papillary thyroid carcinoma; Bilaterality; Ultrasonographic findings; Clinicopathologic factors

MeSH Terms

Biopsy, Fine-Needle
Humans
Pathology
Retrospective Studies
Sensitivity and Specificity
Thyroid Gland*
Thyroid Neoplasms*
Thyroidectomy
Ultrasonography*