Korean J Endocr Surg.  2009 Dec;9(4):211-213. 10.16956/kjes.2009.9.4.211.

Thyroid Carcinoma in Patients Less Than 20 Years of Age at Diagnosis: Clinicopathologic Characteristics

Affiliations
  • 1Department of Surgery, Wonju Christian Hospital, Yonsei University College of Medicine, Wonju, Korea. Arihan@yonsei.ac.kr

Abstract

PURPOSE
This study determined the clinicopathologic characteristics in young patients with thyroid carcinoma.
METHODS
We retrospectively reviewed the records of 39 patients who were <20 years of age when diagnosed between January 1985 and December 2008.
RESULTS
The mean age was 17.28 years (range, 4~20 years). There were 33 females and 6 males, with a mean follow-up period of 110 months (range, 1~263 months). The initial surgery consisted of total thyroidectomy in 29 patients (74%), and lobectomy and isthmectomy in 10 patients (25%). The mean size of the tumors was 2.56 cm (range 0.4~7 cm), and 31 (79%) of 39 patients had perithyroidal tissue invasion. Papillary and follicular carcinoma was reported in 31 (79%) and 6 patients (15%), respectively. Three patients had a recurrence and no patients had progression of metastasis at the time of diagnosis.
CONCLUSION
Further collaborative studies are needed to refine the surgical approach, particularly the extent of lymph-node dissection, radioactive iodine dosing, and clinical approach.

Keyword

Thyroid carcinoma; Young patients; Clinicopathologic characteristics

MeSH Terms

Diagnosis*
Female
Follow-Up Studies
Humans
Iodine
Male
Neoplasm Metastasis
Recurrence
Retrospective Studies
Thyroid Gland*
Thyroid Neoplasms*
Thyroidectomy
Iodine

Reference

References

1). Halac I, Zimmerman D. Thyroid nodules and cancers in children. Endocrinol Metab Clin N Am. 2005; 34:725–44.
Article
2). Parisi M, Mankoff D. Differentiated pediatric thyroid cancer: correlates with adult disease, controversies in treatment. Semin Nucl Med. 2007; 37:340–56.
Article
3). Winship T, Rosvoll RV. Childhood thyroid carcinoma. Cancer. 1961; 14:734–43.
Article
4). Hung W, Sarlis N. Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a review. Thyroid. 2002; 12:683–703.
Article
5). Chaukar D, Rangarajan V, Nair N, Dcruz A, Nadkarni M, Pai P, et al. Pediatric thyroid cancer. J Surg Oncol. 2005; 92:130–3.
Article
6). Dinauer C, Breuer C, Rivkees A. Differentiated thyroid cancer in children: diagnosis and management. Current Opinion in Oncology. 2008; 20:59–65.
Article
7). Brink J, Heerden J, McIver B, Salomao D, Farley D, Grant C, et al. Papillary thyroid cancer with pulmonary metastases in children: longterm prognosis. Surgery. 2000; 128:881–7.
Article
8). Nam KH, Lim CY, Lee JD, Chang HS, Chung WY, Choi SH, et al. Differentiated thyroid carcinoma in patients less than 20 years of age at diagnosis: clinicopathologic characteristics and prognostic factors. J Korean Surg Soc. 2005; 69:443–9.
9). Buckwalter JA, Gurll NJ, Thomas CG. Cancer of the thyroid in youth. World J Surg. 1981; 5:15–25.
Article
10). Zimmerman D, Hay ID, Gough IR, Goellner JR, Ryan JJ, Grant CS, et al. Papillary thyroid carcinoma in children and adults: longterm follow-up of 1039 patients conservatively treated at one institution during three decades. Surgery. 1988; 104:1157–66.
11). Palmer B, Zarroug A, Poley R, Kollars J, Moir R. Papillary thyroid carcinoma in children: risk factors and complications of disease recurrence. J Pediat Surg. 2005; 40:1284–8.
Article
12). Kumagai A, Reiners C, Drozd V, Yamashita S. Childhood thyroid cancers and radioactive iodine therapy: necessity of precautious radiation health risk management. Endocrine Journal. 2007; 54:839–47.
Article
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