J Cardiovasc Ultrasound.  2017 Mar;25(1):5-11. 10.4250/jcu.2017.25.1.5.

The Relationships between Body Mass Index and Left Ventricular Diastolic Function in a Structurally Normal Heart with Normal Ejection Fraction

• Seo JS
• Jin HY
• Jang JS
• Yang TH
• Kim DK
• Kim DS

• KMID: 2375291
• DOI: http://doi.org/10.4250/jcu.2017.25.1.5

Abstract

BACKGROUND
We conducted research to determine the effect of the weight on left ventricular (LV) diastolic function in Asians, who are at greater risk of cardiovascular events compared to individuals from Western countries with similar body mass indices (BMIs).
METHODS
We studied 543 participants with structurally normal hearts and normal ejection fractions. Participants were classified as normal-weight (BMI < 23.0 kg/m²), overweight (BMI 23.0-27.4 kg/m²), or obese (BMI ≥ 27.5 kg/m²). Peak E velocity, peak A velocity, and E"² velocity were measured and E/E"² was calculated.
RESULTS
Overweight participants had lower E than normal-weight participants (p = 0.001). E"² velocities in overweight and obese participants were less than those in normal weight participants (both p < 0.001). The E/E"² ratio in obese participants was higher compared to the value in normal-weight participants (p < 0.001) and overweight participants (p = 0.025). BMI was associated with E (R = −0.108), A (R = 0.123), E"² (R = −0.229), and E/E"² ratio (R = 0.138) (all p < 0.05). In multivariate analyses, BMI was independently associated with higher A, lower E"², and higher E/E"². The risk of diastolic dysfunction was significantly higher among overweight [adjusted odds ratio: 2.088; 95% confidence interval (CI): 1.348-3.235; p = 0.001] and obese participants (adjusted odds ratio: 5.910; 95% CI: 2.871-12.162; p < 0.001) compared to normal-weight participants.
CONCLUSION
Obesity and overweight independently predicted diastolic dysfunction. An optimal body weight lower than the universal cut-off is reasonable for preventing LV heart failure in Asians.

Keyword

Body weight; Obese; Diastole; Body mass index; Asian

MeSH Terms

Asian Continental Ancestry Group
Body Mass Index*
Body Weight
Diastole
Heart Failure
Heart*
Humans
Multivariate Analysis
Obesity
Odds Ratio
Overweight

Figure

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  Fig. 1 Proportion of diastolic dysfunction in each weight group.

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