Pediatr Gastroenterol Hepatol Nutr.  2017 Mar;20(1):41-46. 10.5223/pghn.2017.20.1.41.

Effect of the Baseline Vitamin D Level on Growth Outcome in Pediatric Crohn Disease

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. mjschj@snu.ac.kr

Abstract

PURPOSE
Vitamin D deficiency is common in Crohn disease (CD). The aim of the study was to examine the prevalence of vitamin D deficiency and evaluate the association between vitamin D status and growth outcome in Korean pediatric CD patients.
METHODS
In this retrospective study, 17 children younger than 18 years old diagnosed with CD were enrolled and their serum 25-hydroxy vitamin D (25[OH]D) was checked between 2011 and 2015. We categorized the patients into two groups, Group 1 and Group 2. Group 1 included patients with serum 25(OH)D levels below 10 ng/mL, and Group 2 was for patients with a 25(OH)D serum levels between 10 ng/mL and 30 ng/mL. The z-scores for height (Htz), weight (Wtz), and body mass index (BMIz) were measured at baseline, 6 months, and 12 months.
RESULTS
The mean serum 25(OH)D levels of the total 65 CD patients and 17 enrolled patients were 15.64±6.9 ng/mL and 13.1±5.1 ng/mL, respectively. There was no correlation at the beginning of the study between vitamin D level and growth parameters (Htz, Wtz, BMIz) or other variables including laboratory data and Pediatric Crohn Disease Activity Index. The Htz, Wtz, and BMIz in Group 1 showed no significant improvement at 6 months and 12 months follow-up. In Group 2, Wtz and BMIz showed significant improvements sustained until 12 months of follow-up. Htz showed no significant improvement at 6 months but there was significant improvement at 12 months.
CONCLUSION
It seems that baseline vitamin D status affects growth outcome in pediatric CD.

Keyword

Pediatric Crohn's disease; Vitamin D; Growth

MeSH Terms

Body Mass Index
Child
Crohn Disease*
Follow-Up Studies
Humans
Prevalence
Retrospective Studies
Vitamin D Deficiency
Vitamin D*
Vitamins*
Vitamin D
Vitamins

Cited by  1 articles

Therapeutic Efficacy of Exclusive Enteral Nutrition with Specific Polymeric Diet in Pediatric Crohn's Disease
Yunkoo Kang, Sowon Park, Seung Kim, Sang Yong Kim, Hong Koh
Pediatr Gastroenterol Hepatol Nutr. 2019;22(1):72-79.    doi: 10.5223/pghn.2019.22.1.72.


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