Blood Res.  2017 Mar;52(1):62-64. 10.5045/br.2017.52.1.62.

Therapy-related acute promyelocytic leukemia in plasma cell myeloma treated with melphalan: a case report and literature review

• Gu H
• Kim YJ
• Lee WI
• Lee J
• Yoon HJ
• Park TS

• KMID: 2375206
• DOI: http://doi.org/10.5045/br.2017.52.1.62

Abstract

No abstract available.

MeSH Terms

Leukemia, Promyelocytic, Acute*
Melphalan*
Multiple Myeloma*
Plasma Cells*
Plasma*
Melphalan

Figure

• 

  Fig. 1 Microscopic examination of peripheral blood (PB) and bone marrow (BM) (A) PB shows rouleaux formation of red cells and an atypical promyelocyte. (B) BM aspiration smears shows an increased number of atypical promyelocytes with bilobed nuclei, densely packed large granules in cytoplasm and a few faggot cells (Wright-Giemsa stain ×1,000).

• 

  Fig. 2 (A) Conventional bone marrow chromosome analysis showing 46,XX,t(15;17)(q22;q12). (B) Fluorescence in situ hybridizations for PML-RARA rearrangement showing two fusion signals [nuc ish (PML,RARA) ×3(RARA con PML ×2)].

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