Yonsei Med J.  2016 Mar;57(2):337-341. 10.3349/ymj.2016.57.2.337.

Comparison of Paclitaxel-Coated Balloon Treatment and Plain Old Balloon Angioplasty for De Novo Coronary Lesions

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
  • 2Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. sesim1989@gmail.com
  • 3Division of Cardiology, Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea.
  • 4East Lancashire Hospitals NHS Trust, Blackburn, Lancashire, UK.
  • 5Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.

Abstract

PURPOSE
This study compared the angiographic outcomes of paclitaxel-coated balloon (PCB) versus plain old balloon angioplasty (POBA) treatment for de novo coronary artery lesions. At present, there is no available data comparing the efficacy of PCB versus POBA for the treatment of de novo coronary lesions.
MATERIALS AND METHODS
This multicenter retrospective observational study enrolled patients with de novo coronary lesions with a reference vessel diameter between 2.5 mm and 3.0 mm and lesion length < or =24 mm who were successfully treated with PCB or POBA. Angiographic measurements and quantitative coronary analysis were performed before and after the procedure, and at 9 months follow-up.
RESULTS
A total of 72 patients (49 receiving PCB and 23 receiving POBA) were enrolled in this study. Late luminal loss was -0.12+/-0.30 mm in the PCB group and 0.25+/-0.50 mm in the POBA group (p<0.001). There was a higher percentage of binary restenosis (diameter stenosis > or =50%) in POBA, compared to PCB (30.4%, n=7 vs. 4.1%, n=2, p<0.001). Target vessel revascularization was higher in the POBA group (13.0%, n=3 vs. 0%, p=0.033).
CONCLUSION
PCB treatment of de novo coronary lesions showed better 9-month angiographic outcomes than POBA treatment alone.

Keyword

Paclitaxel-coated balloon; de novo coronary lesion; plain old balloon angioplasty; restenosis; revascularization

MeSH Terms

Aged
Angioplasty, Balloon, Coronary/*instrumentation/methods
Coronary Angiography
Coronary Artery Disease/therapy
Coronary Stenosis/*therapy
Coronary Vessels/pathology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Paclitaxel/*administration & dosage/therapeutic use
Retrospective Studies
Paclitaxel

Cited by  1 articles

A Comparison of Peri-Procedural Myocardial Infarction between Paclitaxel-Coated Balloon and Drug-Eluting Stent on De Novo Coronary Lesions
Ae-Young Her, Kyoung-Im Cho, Gillian Balbir Singh, Scot Garg, Yong Hoon Kim, Bon-Kwon Koo, Eun-Seok Shin
Yonsei Med J. 2017;58(1):99-104.    doi: 10.3349/ymj.2017.58.1.99.


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