Lab Med Online.  2017 Apr;7(2):79-82. 10.3343/lmo.2017.7.2.79.

Two Clinical Cases of Anti-Di(b) with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

  • 1Department of Laboratory Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
  • 2Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
  • 3Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.
  • 4Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.


Here, we report two cases of identified anti-Di(b) antibodies with rare Di(a+b−) blood types from two different hospitals in Korea. Di(b) mismatched transfusion could cause a hemolytic transfusion reaction. However, it is extremely difficult to find compatible blood for patients with such a rare blood type. In this regard, we concluded that national level rare donor registry program, wherein rare blood types are indexed, needs to be established. Moreover, laboratory medicine specialists at each hospital should encourage donor registration and family testing through education for helping patients with rare blood types. These efforts will help establish a system that guarantees safe blood transfusion for patients.


Rare blood donor registry program; Anti-Dib; Transfusion
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