J Korean Med Sci.  2016 Jun;31(6):866-872. 10.3346/jkms.2016.31.6.866.

Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma

• Park HK
• Lee KY
• Yoo MW
• Hwang TS
• Han HS

• KMID: 2373694
• DOI: http://doi.org/10.3346/jkms.2016.31.6.866

Abstract

Mixed carcinoma shows a mixture of glandular and signet ring/poorly cohesive cellular histological components and the prognostic significance of each component is not fully understood. This study aimed to investigate the significance of the poorly cohesive cellular histological component as a risk factor for lymph node metastasis and to examine the diagnostic reliability of endoscopic biopsy. Clinicopathologic characteristics of 202 patients who underwent submucosal invasive gastric carcinoma resection with lymph node dissection in 2005-2012 were reviewed. Mixed carcinoma accounted for 27.2% (56/202) of cases. The overall prevalence of lymph node metastasis was 17.3% (35/202). Lymphatic invasion (P < 0.001), family history of carcinoma (P = 0.025), tumor size (P = 0.004), Lauren classification (P = 0.042), and presence of any poorly cohesive cellular histological component (P = 0.021) positively correlated with the lymph node metastasis rate on univariate analysis. Multivariate analyses revealed lymphatic invasion, family history of any carcinoma, and the presence of any poorly cohesive cellular histological component to be significant and independent factors related to lymph node metastasis. Review of preoperative biopsy slides showed that preoperative biopsy demonstrated a sensitivity of 63.6% and a specificity of 100% in detecting the presence of the poorly cohesive cellular histological component, compared with gastrectomy specimens. The presence of any poorly cohesive cellular histological component was an independent risk factor associated with lymph node metastasis in submucosal invasive gastric carcinoma. Endoscopic biopsy had limited value in predicting the presence and proportion of the poorly cohesive cellular histologic component due to the heterogeneity of mixed carcinoma.

Keyword

Early Gastric Cancer; Lymph Node Metastasis; Biopsy; Mixed Carcinoma; Gastrointestinal Endoscopy

MeSH Terms

Adult
Aged
Aged, 80 and over
Carcinoma/diagnosis/*pathology
Female
Gastrectomy
Gastric Mucosa/*pathology
Gastroscopy
Humans
Lymph Node Excision
Lymphatic Metastasis
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prognosis
Retrospective Studies
Risk Factors
Stomach Neoplasms/diagnosis/*pathology

Figure

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  Fig. 1 Relationship between the proportions of the poorly cohesive cellular histological component in biopsy and resection specimens.

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  Fig. 2 A representative case of mixed carcinoma. (A-C) Between gland forming moderately differentiated tubular adenocarcinoma components (arrows), signet ring/poorly cohesive cellular histological components are present in lamina propria (arrow heads). (D) The signet ring/poorly cohesive cellular histological components show characteristic intracytoplasmic mucin vacuole, which pushes the nucleus to the cell periphery. Magnification: (A) × 40; (B-C) × 200; (D) × 600.

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