J Korean Med Sci.  2016 May;31(5):674-681. 10.3346/jkms.2016.31.5.674.

Knowledge and Perception about Clinical Research Shapes Behavior: Face to Face Survey in Korean General Public

• Choi YJ
• Beck SH
• Kang WY
• Yoo S
• Kim SY
• Lee JS
• Burt T
• Kim TW

• KMID: 2373662
• DOI: http://doi.org/10.3346/jkms.2016.31.5.674

Abstract

Considering general public as potential patients, identifying factors that hinder public participation poses great importance, especially in a research environment where demands for clinical trial participants outpace the supply. Hence, the aim of this study was to evaluate knowledge and perception about clinical research in general public. A total of 400 Seoul residents with no previous experience of clinical trial participation were selected, as representative of population in Seoul in terms of age and sex. To minimize selection bias, every fifth passer-by was invited to interview, and if in a cluster, person on the very right side was asked. To ensure the uniform use of survey, written instructions have been added to the questionnaire. Followed by pilot test in 40 subjects, the survey was administered face-to-face in December 2014. To investigate how perception shapes behavior, we compared perception scores in those who expressed willingness to participate and those who did not. Remarkably higher percentage of responders stated that they have heard of clinical research, and knew someone who participated (both, P < 0.001) compared to India. Yet, the percentage of responders expressed willingness to participate was 39.3%, a significantly lower rate than the result of the India (58.9% vs. 39.3%, P < 0.001). Treatment benefit was the single most influential reason for participation, followed by financial gain. Concern about safety was the main reason for refusal, succeeded by fear and lack of trust. Public awareness and educational programs addressing these negative perceptions and lack of knowledge will be effective in enhancing public engaged in clinical research.

Keyword

Clinical Research Perception; Clinical Trial Participation; Perception of Clinical Trial; Awareness of Clinical Trial; Patient Enrollment

MeSH Terms

Adult
Aged
Awareness
*Biomedical Research
Clinical Trials as Topic
Demography
Female
*Health Knowledge, Attitudes, Practice
Humans
India
Interviews as Topic
Male
Middle Aged
*Perception
Republic of Korea
Surveys and Questionnaires
Young Adult

Figure

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  Fig. 1 Reason for participation (multiple responses).

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  Fig. 2 Reason for refusal (multiple responses).

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  Fig. 3 Most trusted source of clinical research information.

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