Ann Lab Med.  2016 Jul;36(4):377-379. 10.3343/alm.2016.36.4.377.

Myelodysplasia-Related Features of Acute Myeloid Leukemia Evolving From Philadelphia-Negative Myeloproliferative Neoplasms

• Kim JR
• Cho YU
• Bae MH
• Kim B
• Jang S
• Seo EJ
• Chi HS
• Park CJ

• KMID: 2373561
• DOI: http://doi.org/10.3343/alm.2016.36.4.377

Abstract

No abstract available.

MeSH Terms

Chromosome Aberrations
Humans
Karyotype
Leukemia, Myeloid, Acute/*diagnosis/etiology/mortality
Myelodysplastic Syndromes/complications/*diagnosis
Myeloproliferative Disorders/complications/*diagnosis
Philadelphia Chromosome
Survival Rate

Figure

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  Fig. 1 The proportion and distribution of individual cytogenetic abnormalities sufficient to diagnose AML with myelodysplasia-related changes in the study patients. No statistical differences were seen between the frequencies of -5/del(5q) in complex karyotypes and isolated -7/del(7q) in the two patient groups.Abbreviations: MPN, myeloproliferative neoplasm; Ph-MPN, Philadelphia chromosome-negative myeloproliferative neoplasm; C, complex karyotype.

• 

  Fig. 2 Overall survival of the study patients. (A) Overall survival of patients with MDS-AML (N=82) and those with MPN-AML (N=21). There was no significant difference between overall survival rates in the 2 patient groups. (B) Overall survival of MPN-AML patients stratified by the presence or absence of MRC features. Patients with MRC features (N=13) had shorter overall survival than patients without (N=8; P=0.008).Abbreviations: MPN, myeloproliferative neoplasm; MRC, myelodysplasia-related changes.

Reference

1. Arber DA, Porwit A, Brunning RD, Vardiman JW, Orazi A, Le Beau MM, et al. Acute myeloid leukaemia with myelodysplasia-related changes. In : Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC;2008. p. 124–126.

2. Weinberg OK, Seetharam M, Ren L, Seo K, Ma L, Merker JD, et al. Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system. Blood. 2009; 113:1906–1908. PMID: 19131546.

3. Tallarico M, Odenike O. Secondary acute myeloid leukemias arising from Philadelphia chromosome negative myeloproliferative neoplasms: pathogenesis, risk factors, and therapeutic strategies. Curr Hematol Malig Rep. 2015; 10:112–117. PMID: 25893311.

4. Nguyen-Khac F, Lesty C, Eclache V, Couronné L, Kosmider O, Andrieux J, et al. Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations. Genes Chromosomes Cancer. 2010; 49:919–927. PMID: 20629097.

5. Gangat N, Tefferi A, Thanarajasingam G, Patnaik M, Schwager S, Ketterling R, et al. Cytogenetic abnormalities in essential thrombocythemia: prevalence and prognostic significance. Eur J Haematol. 2009; 83:17–21. PMID: 19236446.

6. Xu XQ, Wang JM, Gao L, Qiu HY, Chen L, Jia L, et al. Characteristics of acute myeloid leukemia with myelodysplasia-related changes: A retrospective analysis in a cohort of Chinese patients. Am J Hematol. 2014; 89:874–881. PMID: 24861848.

7. Devillier R, Gelsi-Boyer V, Brecqueville M, Carbuccia N, Murati A, Vey N, et al. Acute myeloid leukemia with myelodysplasia-related changes are characterized by a specific molecular pattern with high frequency of ASXL1 mutations. Am J Hematol. 2012; 87:659–662. PMID: 22535592.

8. Zemanova Z, Michalova K, Buryova H, Brezinova J, Kostylkova K, Bystricka D, et al. Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis. Leuk Res. 2014; 38:537–544. PMID: 24636338.

9. Granfeldt Østgård LS, Medeiros BC, Sengeløv H, Nørgaard M, Andersen MK, Dufva IH, et al. Epidemiology and clinical significance of secondary and therapy-related acute myeloid leukemia: A national population-based cohort study. J Clin Oncol. 2015; 33:3641–3649. PMID: 26304885.