Neurointervention.  2017 Mar;12(1):20-30. 10.5469/neuroint.2017.12.1.20.

Alberta Stroke Program Early CT Score in the Prognostication after Endovascular Treatment for Ischemic Stroke: A Meta-analysis

Affiliations
  • 1Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea. md.cwryu@gmail.com
  • 2Department of Neurosurgery, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea.
  • 3Department of Neurology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea.
  • 4Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Abstract

PURPOSE
The Alberta Stroke Program Early CT Score (ASPECTS) was devised to quantify the extent of early ischemic changes in the middle cerebral artery territory on brain CT. We performed a systematic review and meta-analysis of studies that presented clinical outcomes and baseline ASPECTS in ischemic stroke patients managed with endovascular methods to validate the use of ASPECTS for risk prognostication.
MATERIALS AND METHODS
We searched the MEDLINE, EMBASE, and Cochran databases for observational or interventional studies that reported clinical outcomes and baseline ASPECTS in ischemic stroke patients treated with endovascular methods. Data were pooled to perform a meta-analysis for comparisons of clinical outcomes between high and low ASPECTS patients.
RESULTS
A meta-analysis of 13 studies (six observational and seven interventional) revealed favorable outcomes (mRS sore 0-2 at 90 days) for high baseline ASPECTS (odds ratio=2.22; 95% CI: 1.74-2.86).
CONCLUSION
High ASPECTS is a predictor of favorable outcome after endovascular therapy for ischemic stroke.

Keyword

ASPECTS score; Stroke; Thrombectomy; Reperfusion therapy

MeSH Terms

Alberta*
Brain
Humans
Middle Cerebral Artery
Stroke*
Thrombectomy
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