Korean J Biol Psychiatry.
2017 Feb;24(1):1-9. 10.0000/kjbp.2017.24.1.1.
Animal Models of Demyelination and ¹H-Magnetic Resonance Spectroscopy
- Affiliations
-
- 1The Brain Institute, University of Utah, Salt Lake City, UT, USA.
- 2Ewha Brain Institute, Ewha Womans University, Seoul, Korea. jungyoon.kimm@ewha.ac.kr
- 3Department of Brain and Cognitive Sciences, Division of Convergence, Scranton College, Ewha Womans University, Seoul, Korea.
- 4Interdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University, Seoul, Korea.
- 5Department of Radiology, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, Korea.
- 6Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.
- 7Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea.
- KMID: 2371177
- DOI: http://doi.org/10.0000/kjbp.2017.24.1.1
Abstract
- The proton magnetic resonance spectroscopy (¹H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
MeSH Terms
-
Animals*
Aspartic Acid
Autoimmune Diseases
Brain
Butyric Acid
Choline
Creatine
Demyelinating Diseases*
Encephalomyelitis
Glutamic Acid
Humans
Models, Animal*
Multiple Sclerosis
Myelin Sheath
Neurons
Pathologic Processes
Proton Magnetic Resonance Spectroscopy
Rodentia
Spectrum Analysis*
Aspartic Acid
Butyric Acid
Choline
Creatine
Glutamic Acid
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