Ann Lab Med.  2017 May;37(3):285-287. 10.3343/alm.2017.37.3.285.

NUP98 Rearrangement in Acute Myelomonocytic Leukemia With t(11;19)(p15;p12): The First Case Report Worldwide

• Lim HH
• An GD
• Woo KS
• Kim KH
• Kim JM
• Kim SH
• Han JY

• KMID: 2369757
• DOI: http://doi.org/10.3343/alm.2017.37.3.285

Abstract

No abstract available.

MeSH Terms

Leukemia, Myelomonocytic, Acute*

Figure

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  Fig. 1 Findings of the bone marrow (BM) aspirate smear and Giemsa-banded karyogram. (A) Leukemic blasts with mixed myeloblasts and monoblasts on the BM aspirate smear (Wright-Giemsa stain, ×1,000). (B) Giemsa-banded karyogram of the BM cells at diagnosis: 46,XX, t(11;19)(p15;p12). The vertical arrows indicate abnormal chromosomes.

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  Fig. 2 The whole-genome sequencing (WGS) and FISH analyses. (A) Circos plot showing the in-frame gene fusions discovered in the WGS analysis. The lines traversing the ring indicate the gene fusions between each involved gene, and the outermost digits, X, and Y represent each chromosome number. The horizontal arrow points to the line indicating the fusion between NUP98 at chromosome 11p15.4 and ZNF91 at 19p12. (B) Metaphase FISH with the NUP98 break-apart probe. The vertical arrows indicate the presence of a break-apart rearrangement at chromosome 11p15.

Reference

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