Anesth Pain Med.  2017 Jan;12(1):37-41. 10.17085/apm.2017.12.1.37.

The effect of pre-anesthetic administration of dexmedetomidine on the consumption of opioids in postoperative gynecologic patients

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. sunnyrhee@paik.ac.kr

Abstract

BACKGROUND
This study was designed to assess whether pre-anesthetic administration of dexmedetomidine reduces the postoperative consumption of opioids, in patients receiving patient-controlled fentanyl after gynecological laparotomy.
METHODS
This was a prospective, randomized, double-blind, controlled study. Ten minutes before induction of anesthesia, 36 patients scheduled for elective gynecological laparotomy were assigned to receive either normal saline (group N) or dexmedetomidine 1 µg/kg (group D). A patient-controlled analgesia (PCA) device was used to administer fentanyl for the postoperative 24 h period. Cumulative fentanyl consumption and pain score were assessed at postoperative 30 min, 6 h and 24 h. Patient's satisfaction for pain control and other side effects (nausea, sedation score) were recorded for all corresponding time points.
RESULTS
There was no significant difference between the groups in cumulative fentanyl consumption (Group N: 11.1 ± 3.2 µg/kg, Group D: 10.3 ± 2.9 µg/kg, P value: 0.706). The incidence of side-effects did not differ between the groups. Both groups showed similar blood pressure after anesthesia induction. However, 10 min after anesthesia induction, the heart rates in group D were significantly lower than group N (P = 0.0002).
CONCLUSIONS
In patients undergoing gynecological laparotomy, the pre-anesthetic administration of single loading dose dexmedetomidine (1 µg/kg) given 10 min before anesthesia induction did not reduce the PCA consumption of postoperative fentanyl or the pain score.

Keyword

Adrenergic alpha-2 receptor agonists; Dexmedetomidine; Fentanyl; Patient-controlled analgesia; Postoperative pain

MeSH Terms

Adrenergic alpha-2 Receptor Agonists
Analgesia, Patient-Controlled
Analgesics, Opioid*
Anesthesia
Blood Pressure
Dexmedetomidine*
Fentanyl
Heart Rate
Humans
Incidence
Laparotomy
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Prospective Studies
Adrenergic alpha-2 Receptor Agonists
Analgesics, Opioid
Dexmedetomidine
Fentanyl
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