Ann Dermatol.  2017 Feb;29(1):131-133. 10.5021/ad.2017.29.1.131.

Infliximab for Treatment of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome: A Case Report

• Hirohata A
• Hanafusa T
• Kawamoto T
• Ikegami R

• KMID: 2368051
• DOI: http://doi.org/10.5021/ad.2017.29.1.131

Abstract

No abstract available.

MeSH Terms

Acne Vulgaris*
Hyperostosis*
Infliximab*
Osteitis*
Synovitis*
Infliximab

Figure

• 

  Fig. 1 Physical findings. (A) On admission, the patient had multiple erythematous follicular papules and pustules, approximately 5 mm in diameter, on the forehead, lower jaw, and posterior neck. Multiple scars from healed acne lesions on the back and bilateral forearms were also noted. (B) Physical findings after a single intravenous dose of ibandronic acid and fifth infusion of infliximab. The acne lesions almost disappeared from the face.

• 

  Fig. 2 Evaluation of bone and joint lesions before the infusion of infliximab. (A) Bone scintigraphy shows abnormal radioisotope accumulation at the sacroiliac joints. (B) Enhanced magnetic resonance imaging using short inversion time (TI) inversion recovery sequences shows increased signal intensity at the sacroiliac joints and the iliums.

Reference

1. Iqbal M, Kolodney MS. Acne fulminans with synovitis-acnepustulosis-hyperostosis-osteitis (SAPHO) syndrome treated with infliximab. J Am Acad Dermatol. 2005; 52:5 Suppl 1. S118–S120.

2. Yiu ZZ, Madan V, Griffiths CE. Acne conglobata and adalimumab: use of tumour necrosis factor-α antagonists in treatment-resistant acne conglobata, and review of the literature. Clin Exp Dermatol. 2015; 40:383–386.

3. Wagner AD, Andresen J, Jendro MC, Hülsemann JL, Zeidler H. Sustained response to tumor necrosis factor alpha-blocking agents in two patients with SAPHO syndrome. Arthritis Rheum. 2002; 46:1965–1968.

4. Olivieri I, Padula A, Ciancio G, Salvarani C, Niccoli L, Cantini F. Successful treatment of SAPHO syndrome with infliximab: report of two cases. Ann Rheum Dis. 2002; 61:375–376.

5. Delattre E, Guillot X, Godfrin-Valnet M, Prati C, Wendling D. SAPHO syndrome treatment with intravenous pamidronate. Retrospective study of 22 patients. Joint Bone Spine. 2014; 81:456–458.