Clin Psychopharmacol Neurosci.  2017 Feb;15(1):70-72. 10.9758/cpn.2017.15.1.70.

Mania in Wolfram's Disease: From Bedside to Bench

Affiliations
  • 1Department of Psychiatry, Medical College, Calcutta National Medical College, Kolkata, India.
  • 2Consultant Psychiatrist, Calcutta National Medical College, Kolkata, India. sayantanava@gmail.com
  • 3Department of Endocrinology, Calcutta National Medical College, Kolkata, India.

Abstract

Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific WFS1 gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.

Keyword

Wolfram syndrome; Bipolar Disorder; Comorbidity
Full Text Links
  • CPN
Share
  • Twitter
  • Facebook
Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr