Clin Psychopharmacol Neurosci.  2017 Feb;15(1):70-72. 10.9758/cpn.2017.15.1.70.

Mania in Wolfram's Disease: From Bedside to Bench

  • 1Department of Psychiatry, Medical College, Calcutta National Medical College, Kolkata, India.
  • 2Consultant Psychiatrist, Calcutta National Medical College, Kolkata, India.
  • 3Department of Endocrinology, Calcutta National Medical College, Kolkata, India.


Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific WFS1 gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.


Wolfram syndrome; Bipolar Disorder; Comorbidity
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