Cancer Res Treat.  2017 Jan;49(1):141-149. 10.4143/crt.2016.133.

Reactive Oxygen Species Modulator 1 (Romo1) Predicts Poor Outcomes in Advanced Non-small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy

• Lee SH
• Choi SI
• Lee JS
• Kim CH
• Jung WJ
• Lee EJ
• Min KH
• Hur GY
• Lee SH
• Lee SY
• Kim JH
• Lee SY
• Shin C
• Shim JJ
• Kang KH
• In KH

• KMID: 2367511
• DOI: http://doi.org/10.4143/crt.2016.133

Abstract

PURPOSE
Reactive oxygen species modulator 1 (Romo1) is a key mediator of intracellular reactive oxygen species production. However, examination of the clinical usefulness of Romo1 in cancers has been limited. We evaluated the association of Romo1 expression with clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.
MATERIALS AND METHODS
Romo1 expression in tumor tissue was examined by immunohistochemistry and evaluated by histological score. Survival analyses were performed according to Romo1 expression and the association between Romo1 expression and clinical parameters was evaluated.
RESULTS
A total of 88 tumor specimens were analyzed. Significantly shorter median progression-free survival (PFS) was observed in the high Romo1 group compared with the low Romo1 group (4.5 months vs. 9.8 months, p < 0.001), and the median overall survival (OS) of the high Romo1 group was also significantly shorter than that of the low Romo1 group (8.4 months vs. 15.5 months, p < 0.001). Results of multivariate analyses showed significant association of high Romo1 expression with both poor PFS (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.71 to 4.44) and poor OS (HR, 3.99; 95% CI, 2.36 to 6.74). Results of the subgroup analysis showed a similar association regardless of tumor histology. Romo1 expression showed no association with any clinical parameter including age, sex, smoking status, stage, differentiation, or tumor histology.
CONCLUSION
Romo1 overexpression was associated with poor response to treatment and shorter survival in advanced NSCLC patients treated with platinum-based chemotherapy. Romo1 could be a potential adverse predictive marker in this setting.

Keyword

Lung neoplasms; Biomarkers; Reactive oxygen species; Prognosis; Drug therapy; Platinum

MeSH Terms

Biomarkers
Carcinoma, Non-Small-Cell Lung*
Disease-Free Survival
Drug Therapy*
Humans
Immunohistochemistry
Lung Neoplasms
Multivariate Analysis
Platinum
Prognosis
Reactive Oxygen Species*
Smoke
Smoking
Biomarkers
Platinum
Reactive Oxygen Species
Smoke

Figure

• 

  Fig. 1. Representative samples of immunochemical staining for Romo1 with different H scores (×200). Romo1 was primarily detected in the cytoplasm of adenocarcinoma and squamous cell carcinoma cells. (A) H score of 50. (B) H score of 150. (C) H score of 250. Romo1, reactive oxygen species modulator 1; H scores, histological scores; ADC, adenocarcinoma; SQCC, squamous cell carcinoma.

• 

  Fig. 2. Kaplan-Meier survival curves for progression-free survival (PFS) (A) and overall survival (OS) (B) in the overall population. p-values were determined using the log-rank test. Romo1, reactive oxygen species modulator 1.

Reference

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