Chonnam Med J.  2017 Jan;53(1):73-77. 10.4068/cmj.2017.53.1.73.

Association between Serum 25-hydroxyvitamin D Levels and Type 2 Diabetes in Korean Adults

Affiliations
  • 1Dong-gu Public Health Center, Gwangju, Korea.
  • 2Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. hykim615@gmail.com
  • 3Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Korea.
  • 4Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Korea.
  • 5Department of Preventive Medicine, Chungnam National University Medical School, Daejeon, Korea.
  • 6Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Korea.
  • 7Department of Preventive Medicine, Chosun University Medical School, Gwangju, Korea.

Abstract

Previous studies have suggested that a vitamin D deficiency increases the risk of type 2 diabetes. This study evaluated the association between serum vitamin D levels and type 2 diabetes in Korean adults. This study included 9,014 subjects (3,600 males and 5,414 females) aged ≥50 years who participated in the Dong-gu Study. The subjects were divided into groups in whom the serum vitamin D level was severely deficient (<10 ng/mL), deficient (10 to <20 ng/mL), insufficient (20 to <30 ng/mL) and sufficient (≥30 ng/mL). Type 2 diabetes was defined by a fasting blood glucose level of ≥126 mg/dL and/or an HbA1c proportion of ≥6.5% and/or self-reported current use of diabetes medication. Multiple logistic regression was performed to evaluate the association between vitamin D status and type 2 diabetes. The age- and sex-adjusted prevalence of type 2 diabetes was 22.6%, 22.5% and 18.4% and 12.7% for severely deficient, deficient, insufficient, and sufficient, respectively. Multivariate modeling revealed that subjects with insufficient or sufficient vitamin D levels were at a lower risk of type 2 diabetes than were subjects with deficient vitamin D levels [odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71-0.94 and OR, 0.51; 95% CI, 0.35-0.74, respectively]. Higher serum vitamin D levels were associated with a reduced risk of diabetes in Korean adults, suggesting that vitamin D may play a role in the pathogenesis of diabetes.

Keyword

Vitamin D; Diabetes Mellitus, Type 2; Cross-Sectional Study; Vitamin D Deficiency
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