Nat Prod Sci.  2016 Dec;22(4):225-230. 10.20307/nps.2016.22.4.225.

Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm

  • 1Department of Chemistry, Faculty of Science, University, Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia.
  • 2School of Chemistry and Environment Studies, Faculty of Applied Sciences, University Teknologi MARA (UiTM) Sarawak Jalan Meranek, 94300 Kota Samarahan, Sarawak, Malaysia.
  • 3Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia.


Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 - 504.2 µM and 21.0 - 59.4 µM, respectively.


Anticholinesterase; Anti-inflammatory; Lignan; Beilschmiedia pulverulenta

MeSH Terms

Cyclooxygenase 2
Inhibitory Concentration 50
Cyclooxygenase 2


  • Fig. 1. Chemical structures of isolated compounds (1 – 9) from B. pulverulenta.



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