Nat Prod Sci.  2016 Dec;22(4):225-230. 10.20307/nps.2016.22.4.225.

Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm

• Salleh WM
• Ahmad F
• Yen KH
• Zulkifli R

• KMID: 2366688
• DOI: http://doi.org/10.20307/nps.2016.22.4.225

Abstract

Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 - 504.2 µM and 21.0 - 59.4 µM, respectively.

Keyword

Anticholinesterase; Anti-inflammatory; Lignan; Beilschmiedia pulverulenta

MeSH Terms

Acetylcholine
Cyclooxygenase 2
Inhibitory Concentration 50
Lignans
Acetylcholine
Cyclooxygenase 2
Lignans

Figure

• 

  Fig. 1. Chemical structures of isolated compounds (1 – 9) from B. pulverulenta.

Reference

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