Allergy.  1995 Mar;15(1):69-74.

Standardization of Inhalation Bronchial Provocation Tests: Pari Inhalierboy and Pulmo Aide Dosimeter

• Yoon HJ
• Choi DC
• Kim YY
• Cho SH
• Min KU

Abstract

Inhalation bronchial provocation tests have been used extensively for several decades as a means of diagnostic testing, occupational screening, research, and epidemiology. To improve comparison of results obtained at different times and in different laboratories, standardization of inhalation bronchial provocation tests and comparison of methods of aerosol generation and inhalation is required. We compared two widely used methods in Korea by measuring provocative concentration producing a 20 % decrease in FEV1 (PC20rnet) in 19 patients with bronchial asthma. In contin uous nubulizer, Pari Inhalierboy method, acrosol was inhaled during self controlled deep inspiration for 5times from functional residual capacity(FRC) to total lung capacity(TLC). In the other Pulmo Aide dosimeter method using DeVilbiss 646 nebulizer, aerosol was inhaled during the first 0.6 second of each of 5 inspiratory capacity breaths from FRC. The measurements with each other were performed at an interval of at least 4 days in random order. The results were as follows; 1. A good correlation between Pari Inhalierboy method and Pulmo Aide dosimeter method existed (4 = 0.91 ). 2. There was a significant difference between the PC20met values by Pari Inhalierboy and those by dosimeter method(12.91mg/ml vs 7.73 mg/ml) In conclusion, dosimeter methods showed a good correlation with Pari Inhalierboy. Since PC20net values measured by dosimeter method is lower than those by Pari Inhalierboy method, it is necessary to try methacholine concentration upto 50 mg/ml in some cases using Pari Inhalierboy method.

MeSH Terms

Asthma
Bronchial Provocation Tests*
Diagnostic Tests, Routine
Epidemiology
Humans
Inhalation*
Inspiratory Capacity
Korea
Lung
Mass Screening
Methacholine Chloride
Nebulizers and Vaporizers
Methacholine Chloride