Psychiatry Investig.  2017 Jan;14(1):107-109. 10.4306/pi.2017.14.1.107.

Reconsidering Clinical Staging Model: A Case of Genetic High Risk for Schizophrenia

  • 1Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • 2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • 3Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea.


The clinical staging model is considered a useful and practical method not only in dealing with the early stage of psychosis overcoming the debate about diagnostic boundaries but also in emerging mood disorder. However, its one limitation is that it cannot discriminate the heterogeneity of individuals at clinical high risk for psychosis, but lumps them all together. Even a healthy offspring of schizophrenia can eventually show clinical symptoms and progress to schizophrenia under the influence of genetic vulnerability and environmental stress even after the peak age of onset of schizophrenia. Therefore, individuals with genetic liability of schizophrenia may require a more intensive intervention than recommended by the staging model based on current clinical status.


Clinical staging model; Schizophrenia; Clinical high risk; Genetic vulnerability
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