Psychiatry Investig.  2017 Jan;14(1):86-92. 10.4306/pi.2017.14.1.86.

Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder

Affiliations
  • 1Department of Psychiatry, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi, Japan. takashiw@dokkyomed.ac.jp
  • 2Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi, Japan.
  • 3Sakura La Mental Clinic, Utsunomiya, Tochigi, Japan.

Abstract

OBJECTIVE: Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population.
METHODS
In this age- and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), −1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD.
RESULTS
No significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the −1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the −1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047).
CONCLUSION
In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.

Keyword

Panic disorder; Serortonin transporter gene linked polymorphic region; Serotonin 1A receptor; Catechol-O-methyltransferase
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