J Clin Neurol.  2017 Jan;13(1):71-76. 10.3988/jcn.2017.13.1.71.

Migraine Susceptibility Genes in Han Chinese of Fujian Province

• Lin QF
• Chen ZC
• Fu XG
• Yang J
• Cao LY
• Yao LT
• Xin YT
• Huang GB

• KMID: 2364900
• DOI: http://doi.org/10.3988/jcn.2017.13.1.71

Abstract

BACKGROUND AND PURPOSE
Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population.
METHODS
This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction"”restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients.
RESULTS
The frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05).
CONCLUSIONS
Our findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.

Keyword

migraine; single-nucleotide polymorphism; genotype; aura; rs4379368; rs10504861; rs12134493

MeSH Terms

Asian Continental Ancestry Group*
Case-Control Studies
Epilepsy
Genotype
Humans
Migraine Disorders*
Migraine with Aura
Migraine without Aura
Polymorphism, Single Nucleotide

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