Korean J Ophthalmol.  2015 Oct;29(5):354-356. 10.3341/kjo.2015.29.5.354.

Intravitreal Bevacizumab for the Treatment of Optic Disc Edema in a Patient with POEMS Syndrome

• Kim DW
• Kang SY
• Bae HW
• Hong S
• Seong GJ
• Kim CY

• KMID: 2363812
• DOI: http://doi.org/10.3341/kjo.2015.29.5.354

Abstract

No abstract available.

MeSH Terms

Adult
Angiogenesis Inhibitors/administration & dosage
Bevacizumab/*administration & dosage
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Intravitreal Injections
Optic Disk/*pathology
POEMS Syndrome/*complications/diagnosis
Papilledema/diagnosis/*drug therapy/etiology
Angiogenesis Inhibitors
Bevacizumab

Figure

• 

  Fig. 1 Fundus photographs, fluorescein angiograms, and Humphrey automated perimetry (HAP) before and 3 months after the last intravitral bevacizumab Injection. (A,B) Bilateral fundus photographs showing optic nerve head edema (ODE). The disc is congested and hyperemic with elevation of the retinal surface. Signs of secondary gliosis due to long term ODE are evident (fundus camera; Canon, Tokyo, Japan) (A, right eye; B, left eye). (C,D) Bilateral fluorescein angiograms and indocyanine green angiograms showing early irregular hyperfluorescence emanating from the disc and spreading to the proximal vascular arcades. Long standing fibrotic change, probably due to secondary gliosis, is also present. Indocyanine green angiograms A shows mild blocked-fluorescence at the disc with no abnormal choroidal perfusion (0:58.23, 30 degrees; Heidelberg Retinal Angiogram 2, Heidelberg Engineering, Heidelberg, Germany) (C, right eye; D, left eye). (E,F) Bilateral fundus photographs 3 months after the last intravitreal bevacizumab injections. Resolution of the prior ODE is evident (E, right eye; F, left eye). (G,H) Bilateral fluorescein angiograms of the same patient 3 months after the last injection of intravitreal bevacizumab. The disc is only mildly stained in the late phase, with no evidence of active leakage (20:04.09) (G, right eye; H, left eye). (I,J) Pre-injection HAP showing enlarged inferior blind spots and superior arcuate visual field defects developing in the right (I) and left (J) eyes, respectively. (K,L) HAP three months after the last intravitreal bevacizumab injection showing resolution of the previous scotomata with a small nasal step remaining in the left eye (K, right eye; L, left eye).

Reference

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