J Vet Sci.  2016 Mar;17(1):111-113. 10.4142/jvs.2016.17.1.111.

Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs

  • 1Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata, Buenos Aires B 1900 AVW, Argentina. cgobello@fcv.unlp.edu.ar


To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm2 of endometrium nor in the height of the uterine epithelium.


canid; contraception; endocrine disruption; genital tract; neonatal
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