J Gynecol Oncol.  2016 May;27(3):e24. 10.3802/jgo.2016.27.e24.

Feasibility of laparoscopic cytoreduction in patients with localized recurrent epithelial ovarian cancer

• Paik ES
• Lee YY
• Kim TJ
• Choi CH
• Lee JW
• Kim BG
• Bae DS

• KMID: 2363318
• DOI: http://doi.org/10.3802/jgo.2016.27.e24

Abstract

OBJECTIVE
To assess the feasibility of laparoscopic cytoreduction in patients with localized recurrent epithelial ovarian cancer (EOC) by comparing its outcomes to those of laparotomy.
METHODS
We performed retrospective analysis in 79 EOC patients who had a localized single recurrent site, as demonstrated by computed tomography (CT) scan, magnetic resonance imaging, or positron emission tomography/CT scan; had no ascites; were disease-free for 12 or more months prior; and who had undergone secondary cytoreduction (laparoscopy in 31 patients, laparotomy in 48 patients) at Samsung Medical Center between 2002 and 2013. By reviewing the electronic medical records, we investigated the patients' baseline characteristics, surgical characteristics, and surgical outcomes.
RESULTS
There were no statistically significant differences between laparoscopy and laparotomy patients in terms of age, body mass index, cancer antigen 125 level, tumor type, initial stage, grade, recurrence site, type of procedures used in the secondary cytoreduction, adjuvant chemotherapy, and disease-free interval from the previous treatment. With regards to surgical outcomes, reduced operating time, shorter hospital stay, and less estimated blood loss were achieved in the laparoscopy group. Complete debulking was achieved in all cases in the laparoscopy group.
CONCLUSION
The laparoscopic approach is feasible without compromising morbidity and survival in selected groups of patients with recurrent EOC. The laparoscopic approach can be a possible treatment option for recurrent EOC.

Keyword

Cytoreduction Surgical Procedures; Laparoscopy; Neoplasm Recurrence, Local; Ovarian Neoplasms; Retrospective Studies

MeSH Terms

Adolescent
Adult
Aged
Cytoreduction Surgical Procedures/*methods
Feasibility Studies
Female
Humans
Laparoscopy/methods
Magnetic Resonance Imaging
Middle Aged
Neoplasm Recurrence, Local/diagnostic imaging/*surgery
Neoplasms, Glandular and Epithelial/diagnostic imaging/*surgery
Ovarian Neoplasms/diagnostic imaging/*surgery
Ovary/diagnostic imaging/surgery
Positron-Emission Tomography
Retrospective Studies
Tomography, X-Ray Computed
Young Adult