Ann Lab Med.  2015 Nov;35(6):663-665. 10.3343/alm.2015.35.6.663.

Isochromosome 1q in Childhood Burkitt Lymphoma: The First Reported Case in Korea

• Rim JH
• Kim HS
• Shin S
• Park SJ
• Choi JR

• KMID: 2363276
• DOI: http://doi.org/10.3343/alm.2015.35.6.663

Abstract

No abstract available.

MeSH Terms

Bone Marrow/pathology
Burkitt Lymphoma/*diagnosis/genetics
Child
Chromosomes, Human, Pair 1
Female
Flow Cytometry
Humans
Immunoglobulin Heavy Chains/genetics
Isochromosomes/*genetics
Karyotype
Karyotyping
Proto-Oncogene Proteins c-myc/genetics
Republic of Korea
Translocation, Genetic
Immunoglobulin Heavy Chains
Proto-Oncogene Proteins c-myc

Figure

• 

  Fig. 1 Microscopic morphological examination of the patient's (A) peripheral blood, and (B) bone marrow touch imprint preparation (Wright-Giemsa stain, ×1,000).

• 

  Fig. 2 (A) The G-banded karyotype of the patient. Trypsin-Giemsa banded chromosome analysis at 550-band level shows a marker chromosome, which is suspected to be isochromosome 1q (red arrow), as well as the translocation involving 8q24 and 14q32 (blue arrow). (B) Interphase FISH by using Vysis locus-specific identifier (LSI) dual color IGH/c-MYC probe set (Abbott Molecular/Vysis, Downers Grove, IL, USA). Two fusion signals of the 8q24 (c-MYC) and 14q32 (IGH) probes with an additional red and green signal for c-MYC and IGH, respectively indicate translocation involving the two genes. (C) Interphase FISH by using Metasystems LSI dual color CDKN2C/CKS1B probe set (Metasystems, Altlussheim, Germany). Two green and four red signals for 1p32 (CDKN2C) and 1q21 (CKS1B), respectively indicate the presence of isochromosome 1q.

Reference

1. Djordjević V, Dencić-Fekete M, Jovanović J, Drakulić D, Stevanović M, Janković G, et al. Pattern of trisomy 1q in hematological malignancies: a single institution experience. Cancer Genet Cytogenet. 2008; 186:12–18. PMID: 18786437.

2. Hawkins JM, Wood M, Wright F, Secker-Walker LM. Isochromosome 1q in acute monocytic leukemia: a new nonrandom association. Genes Chromosomes Cancer. 1992; 5:181–183. PMID: 1381955.

3. Lai JL, Fenaux P, Zandecki M, Nelken B, Huart JJ, Deminatti M. Cytogenetic studies in 30 patients with Burkitt's lymphoma or L3 acute lymphoblastic leukemia with special reference to additional chromosome abnormalities. Ann Genet. 1989; 32:26–32. PMID: 2751244.

4. Roug AS, Wendtland P, Bendix K, Kjeldsen E. Supernumerary isochromosome 1, idic(1)(p12), leading to tetrasomy 1q in Burkitt lymphoma. Cytogenet Genome Res. 2014; 142:7–13. PMID: 24217199.

5. Maria Murga Penas E, Schilling G, Behrmann P, Klokow M, Vettorazzi E, Bokemeyer C, et al. Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples. Genes Chromosomes Cancer. 2014; 53:497–515. PMID: 24590883.

6. Wodzinski MA, Watmore AE, Lilleyman JS, Potter AM. Chromosomes in childhood acute lymphoblastic leukaemia: karyotypic patterns in disease subtypes. J Clin Pathol. 1991; 44:48–51. PMID: 1997533.

7. Navid F, Mosijczuk AD, Head DR, Borowitz MJ, Carroll AJ, Brandt JM, et al. Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the Pediatric Oncology Group experience. Leukemia. 1999; 13:135–141. PMID: 10049049.

8. Havelange V, Ameye G, Théate I, Callet-Bauchu E, Mugneret F, Michaux L, et al. Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement. Genes Chromosomes Cancer. 2013; 52:81–92. PMID: 23012230.

9. de Souza MT, Mkrtchyan H, Hassan R, Ney-Garcia DR, de Azevedo AM, da Costa ES, et al. Secondary abnormalities involving 1q or 13q and poor outcome in high stage Burkitt leukemia/lymphoma cases with 8q24 rearrangement at diagnosis. Int J Hematol. 2011; 93:232–236. PMID: 21207210.

10. de la Chapelle A. How do human isochromosomes arise? Cancer Genet Cytogenet. 1982; 5:173–179. PMID: 7066878.