Ann Lab Med.  2015 Mar;35(2):242-245. 10.3343/alm.2015.35.2.242.

Molecular Characteristics of Noroviruses Genogroup I and Genogroup II Detected in Patients With Acute Gastroenteritis

• Ham H
• Oh S
• Seung H
• Jo S

• KMID: 2363186
• DOI: http://doi.org/10.3343/alm.2015.35.2.242

Abstract

Noroviruses are the leading cause of epidemic gastroenteritis, including foodborne outbreak, in Korea. The prevalence of human noroviruses was studied in diarrheal stool samples of patients with acute gastroenteritis by conventional duplex reverse transcription (RT)-PCR. Diarrheal stool samples were collected from 1,685 patients from the local hospitals in Seoul. The prevalence of the noroviruses was 22.8% (222/972 patients) in 2012 and 11.2% (80/713 patients) in 2013, with a total of 17.9% (302/1,685 patients). Genotyping was performed on 302 norovirus-positive stool samples to reveal 5.6% prevalence of genogroup I (GI) (17/302) and 94.4% prevalence of genogroup II (GII) (285/302). The patients with norovirus-associated acute gastroenteritis mostly showed prevalence of GII norovirus, especially GII.4 (64.6%; 195/302).

Keyword

Norovirus; Acute gastroenteritis; Prevalence; GI; GII; GII.4

MeSH Terms

Acute Disease
Feces/virology
Gastroenteritis/*diagnosis/epidemiology/virology
Genotype
Humans
Norovirus/*genetics/isolation & purification
Prevalence
RNA, Viral/genetics/metabolism
Real-Time Polymerase Chain Reaction
RNA, Viral

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