J Korean Ophthalmol Soc.  2016 Dec;57(12):1834-1839. 10.3341/jkos.2016.57.12.1834.

Comparison of 1% Prednisolone and 0.1% Bromfenac Solutions for Preventing Macular Edema after Cataract Surgery

• Jeong HK
• Shin WB
• Seo KY
• Lee J

• KMID: 2362699
• DOI: http://doi.org/10.3341/jkos.2016.57.12.1834

Abstract

PURPOSE
To compare the clinical effectiveness of 1% Prednisolone acetate ophthalmic solution and 0.1% Bromfenac sodium hydrate ophthalmic solution on prevention of cystoid macular edema after cataract surgery.
METHODS
A retrospective chart review of 349 patients who received phacoemulsification with intraocular lens implantation in Severance Hospital from July 2013 to January 2016 was performed. In these patients, 192 eyes received 1% Prednisolone acetate ophthalmic solution, and 157 eyes were treated with topical 0.1% Bromfenac sodium hydrate ophthalmic solution. The incidence and severity of cystoid macular edema (CME) were evaluated by retinal foveal thickness on optical coherence tomography for patients who showed best corrected visual acuity (BCVA) less than 0.5 (log MAR ≥ 0.3).
RESULTS
There was no significant difference between the two groups in age (p = 0.708), sex (p = 0.977), or the side of operated eye (p = 0.443). The two groups showed BCVA 0.04 ± 0.09 (Steroid group) and 0.03 ± 0.07 (nonsteroidal anti-inflammatory drug [NSAID] group) at 1 month after the surgery and the difference was not significant (p = 0.947). One eye in the topical steroid group had cystoid macular edema, and 3 eyes in the steroid group showed elevated intraocular pressure (IOP) over 30 mm Hg. There were no IOP elevations or macular edema in the NSAID group.
CONCLUSIONS
The results showed that 0.1% Bromfenac sodium hydrate ophthalmic solution had a similar effect to 1% Prednisolone acetate ophthalmic solution on preventing CME after cataract surgery. This indicates that topical NSAID can be considered along with topical steroids in order to prevent CME after cataract surgery.

Keyword

Cataract; Cystoid macular edema (CME); Nonsteroidal anti-inflammatory drug (NSAIDs)

MeSH Terms

Cataract*
Humans
Incidence
Intraocular Pressure
Lens Implantation, Intraocular
Macular Edema*
Phacoemulsification
Prednisolone*
Retinaldehyde
Retrospective Studies
Sodium
Steroids
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity
Prednisolone
Retinaldehyde
Sodium
Steroids

Figure

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  Figure 1. Comparison of best-corrected visual acuity (BCVA, log MAR) between steroid group and nonsteroidal anti-in-flammatory drug (NSAID) group over time.

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  Figure 2. Comparison of intraocular pressure (IOP) between steroid group and nonsteroidal anti-inflammatory drug (NSAID) group over time.

Reference

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