Ann Dermatol.  1989 Jul;1(2):69-72. 10.5021/ad.1989.1.2.69.

Treatment of Gonorrhoea

• Kim JH
• Yang HY
• Kim YT

• KMID: 2362119
• DOI: http://doi.org/10.5021/ad.1989.1.2.69

Abstract

Because of increasing resistance of circulating N. gonorrhoeae and frequent failures in the treatment of gonorrhoea, intensive work on gonorrhoea has become of paramount importance. During January 1980-April 1984, at the Choong-Ku VD Clinic in Seoul, 3,340 male patients with uncomplicated gonococcal urethritis were treated with various treatment regimens. Diagnosis of gonorrhoea and declaration of a treatment failure were made on the basis of positive urethral culture. In 1984, the prevalence of Penicillinase Producing N. gonorrhoeae (PPNG) was about 30%, The pretreatment minimun inhibitory concentration of various antibiotics were quite high. Even for non-PPNG urethritis standard penicillin regimens gave unsatisfactory results. For PPNG urethritis, only spectinomycin, cefoperazone and cefotaxim-probenecid regimens gave satisfactory results. No spectmomycin resistant strain of N. gonorrhoeae has been found since 1982 at the Choong-Ku VD Clinic. As an agent of single drug therapy, spectinomycin seems to be one of the most cost effective drugs in the treatment of uncomplicated gonorrhoea in men.

Keyword

PPNG; Spectinomycin; Treatment of gonorrhoea

MeSH Terms

Anti-Bacterial Agents
Cefoperazone
Diagnosis
Drug Therapy
Humans
Male
Penicillinase
Penicillins
Prevalence
Seoul
Spectinomycin
Treatment Failure
Urethritis
Anti-Bacterial Agents
Cefoperazone
Penicillinase
Penicillins
Spectinomycin