Ann Dermatol.  1992 Jan;4(1):32-36. 10.5021/ad.1992.4.1.32.

Paget's Disease of the Male Breast

• Park YM
• Kim JC
• Choi JS
• Kim KH

• KMID: 2361763
• DOI: http://doi.org/10.5021/ad.1992.4.1.32

Abstract

Paget's disease of the breast occurs almost exclusively in women, and is characterized by a unilateral, sharply defined eczematous skin lesion caused by epidermal metastases from underlying ductal adenocarcinoma of the breast. Paget's disease of the male breast is extremely rare. A 61-year-old patient had a skin lesion on the right nipple for 1 year. The lesion was a well defined, brownish, crusted, and keratotic papule, and was associated with an underlying walnut sized, fixed, hard mass and a palpable ipsilateral axillary lymph node. Histologic findings were consistent with Paget's disease. Results of immunoperoxidase staining technigues for S-100 protein and carcinoembryonic antigen were negative. After a modified radical mastectomy and chemotherapy, the patient has been in remission for 12 months.

Keyword

Male breast; Paget's disease of the breast

MeSH Terms

Adenocarcinoma
Breast*
Carcinoembryonic Antigen
Drug Therapy
Female
Humans
Juglans
Lymph Nodes
Male*
Mastectomy, Modified Radical
Middle Aged
Neoplasm Metastasis
Nipples
Paget's Disease, Mammary
S100 Proteins
Skin
Carcinoembryonic Antigen
S100 Proteins