Ann Dermatol.  1993 Jul;5(2):133-136. 10.5021/ad.1993.5.2.133.

A Case of Malignant Melanoma with Multiple Myeloma

• Choi HR
• Cho YW
• Lee SJ
• Ro BI
• Kim SH

• KMID: 2361708
• DOI: http://doi.org/10.5021/ad.1993.5.2.133

Abstract

Malignant melanoma is an uncommon tumor in Korea. To the best of our knowledge, we could not find malignant melanoma with multiple myeloma in Korean literature. A 57-year-old male patient had a 4×5 cm sized, irregular bordered, dark brownish plaque on the left sole, which has extended gradually since about 1 year ago and showed an occasional bleeding tendency. Laboratory examinations revealed a low hemoglobin level, rouleaux formation on peripheral blood, monoclonal gammopathy of IgG-kappa type and Bence-Jones proteinuria. Bone marrow aspiration findings showed markedly increased immature plasma cells suggesting multiple myeloma. Histopathologic findings of the skin biopsy from the left sole revealed proliferation of atypical melanocytes. We performed a surgical excision with a skin graft for malignant melanoma and chemotherapy (melphalan, vincristine and prednisolone) for multiple myeloma.

Keyword

Malignant melanoma; Multiple myeloma

MeSH Terms

Biopsy
Bone Marrow
Drug Therapy
Hemorrhage
Humans
Korea
Male
Melanocytes
Melanoma*
Middle Aged
Multiple Myeloma*
Paraproteinemias
Plasma Cells
Proteinuria
Skin
Transplants
Vincristine
Vincristine