J Bone Metab.  2016 Nov;23(4):191-197. 10.11005/jbm.2016.23.4.191.

Coronary Calcification Is Reversely Related with Bone and Hair Calcium: The Relationship among Different Calcium Pools in Body

Affiliations
  • 1Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. lovesong@ajou.ac.kr
  • 2Department of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 3Department of Family Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Abstract

BACKGROUND
With aging, calcium efflux from bone is increased with age-related bone loss, and it can reduce bone mineral density (BMD). On the contrary, age-related calcium adoption into arterial wall progressively stiffens blood vessels. Theses process insinuates shift of calcium among different pools in body. However, their relationships have not been elucidated yet. So we investigated the correlation among calcium contents in different body pools, such as hair, bone, and blood vessels in women.
METHODS
We analyzed 50 females retrospectively who measured Agatston coronary artery calcium score (CACS), BMD, and hair calcium concentration at a regular health check-up in a university hospital. CACS was achieved by coronary multidetector computed tomography, BMD was measured by dual energy X-ray absorptiometry in the lumbar spine and femur, and hair calcium level was checked by hair tissue mineral analysis.
RESULTS
CACS inversely correlated with BMD (r=-0.280, P=0.049 with lumbar vertebrae 1-4, r=-0.310, P=0.028 with femur neck, r=-0.333, P=0.018 with femur total) and hair calcium concentration (r=-0.352, P=0.012).
CONCLUSIONS
CACS has negative correlation with BMD and hair calcium level in women. Different body calcium pools such as bone, hair and blood vessel significantly correlated each other.

Keyword

Bone density; Calcium; Hair; Homeostasis; Minerals; Vascular calcification

MeSH Terms

Absorptiometry, Photon
Aging
Blood Vessels
Bone Density
Calcium*
Coronary Vessels
Female
Femur
Femur Neck
Hair*
Homeostasis
Humans
Lumbar Vertebrae
Minerals
Miners
Multidetector Computed Tomography
Osteoporosis
Retrospective Studies
Spine
Vascular Calcification
Calcium
Minerals

Figure

  • Fig. 1 Hypothetic diagram of calcium homeostasis in body.

  • Fig. 2 Summary of our study results.


Cited by  1 articles

Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women
Pooneh Salari, Abbasali Keshtkar, Shapour Shirani, Leila Mounesan
J Bone Metab. 2017;24(1):15-21.    doi: 10.11005/jbm.2017.24.1.15.


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