Allergy Asthma Respir Dis.  2016 Nov;4(6):423-428. 10.4168/aard.2016.4.6.423.

Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children

Affiliations
  • 1Department of Pediatrics, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea. MHSOHN@yuhs.ac

Abstract

PURPOSE
Vitamin D is known to play an important role in the regulation of the immune system and in the prevention of allergic disease. Herein, we examined the association between vitamin D and allergic rhinitis (AR) in children.
METHODS
A total of 72 aeroallergen-proven AR and 57 healthy control subjects who visited Severance Children's Hospital between 2012 and 2014 were evaluated. The mean serum 25-hydroxyvitamin D (25(OH)D) level was measured in all subjects to evaluate their vitamin D status.
RESULTS
The mean serum 25(OH)D levels was significantly lower in patients with AR than in controls (19.5±6.4 ng/mL vs. 22.3±5.8 ng/mL, P=0.013). The incidence of AR is higher in the 25(OH)D-insufficient group (15-20 ng/mL) and in the 25(OH)D-deficient group (≤15 ng/mL) compared with the 25(OH)D-sufficient group (>20 ng/mL) (40.3% vs. 84.4% vs. 22.2%, P<0.001). There was no significant difference in the serum 25(OH)D level between subgroups with mild and moderate-to-severe AR symptoms (19.8±6.5 vs. 19.0±6.3, P=0.596). After adjusting for confounding factors, the lower serum vitamin D level groups had increased odds of AR compared with the 25(OH)D-sufficient group (odds ration [95% confidence interval]; 3.67 [1.29-10.38] in the 25(OH)D-insufficient group; P=0.014 and 6.04 [1.49-24.51] in the 25(OH)D-deficient group; P=0.012).
CONCLUSION
The serum vitamin D levels were significantly lower in children with AR compared with healthy controls. Therefore, lower serum level of 25(OH)D may be associated with the development of AR.

Keyword

Allergic rhinitis; Vitamin D; Childhood

MeSH Terms

Child*
Humans
Immune System
Incidence
Rhinitis, Allergic*
Vitamin D
Vitamin D

Figure

  • Fig. 1 Comparison of serum vitamin D levels according to the presence of allergic rhinitis (A) and the Allergic Rhinitis and its Impact on Asthma (ARIA) classification (B). (A) The box plots show the significant difference in the mean 25-hydroxyvitamin D (25(OH)D) levels between the allergic rhinitis and control group. (B) No significant differences were observed among the ARIA classification subgroups. Allergic rhinitis was classified on the basis of the ARIA 2008 guideline. Data are expressed as mean±standard deviation.


Cited by  2 articles

Research on pediatric allergic rhinitis in Korea
Kyung Suk Lee, Yeong Ho Rha
Allergy Asthma Respir Dis. 2018;6(Suppl 1):S58-S65.    doi: 10.4168/aard.2018.6.S1.S58.

Relationship of serum vitamin D and interleukin-31 levels to allergic or nonallergic rhinitis in children
Seong Jun Park, Ji Eun Soh, Moon Soo Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim
Allergy Asthma Respir Dis. 2018;6(1):41-46.    doi: 10.4168/aard.2018.6.1.41.


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