Clin Mol Hepatol.  2015 Dec;21(4):319-325. 10.3350/cmh.2015.21.4.319.

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase

Affiliations
  • 1Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA. yasuko.iwakiri@yale.edu

Abstract

The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.

Keyword

iNOS; NO; Liver sinusoidal endothelial cell; Hepatic stellate cell; Kupffer cell

MeSH Terms

Endothelial Cells/metabolism
Hepatic Stellate Cells/metabolism
Humans
Kupffer Cells/metabolism
Liver Cirrhosis/metabolism/*pathology
Nitric Oxide/*metabolism
Nitric Oxide Synthase Type II/antagonists & inhibitors/genetics/*metabolism
Polymorphism, Single Nucleotide
RNA, Untranslated/metabolism
RNA, Untranslated
Nitric Oxide
Nitric Oxide Synthase Type II
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