Korean J Gastroenterol.
2016 Sep;68(3):138-142. 10.4166/kjg.2016.68.3.138.
Current Status of Translational Research on Irritable Bowel Syndrome
- Affiliations
-
- 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
- 2Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. imdrkim@naver.com
- KMID: 2358715
- DOI: http://doi.org/10.4166/kjg.2016.68.3.138
Abstract
- Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. The pathophysiology of IBS is not completely understood. Genetic, immune, environmental, inflammatory, neurological and psychological factors contribute to the risk of this condition. Traditional research explored gastrointestinal motor abnormalities, central neural dysregulation, abnormal psychological features, and visceral hypersensitivity. More recent investigations consider bacterial overgrowth, abnormal serotonin pathways, altered gut flora, immune activation and mucosal inflammation. The purpose of this article is to review recent translational research concerning the pathophysiology, biomarker and genetic factors of IBS and to encourage IBS research in Korea.
