J Korean Geriatr Psychiatry.  2016 Oct;20(2):96-101. 10.0000/jkgp.2016.20.2.96.

Impact of Metabolic Syndrome on the White Matter Integrity in Alzheimer's Disease Patients : Tract-Based Spatial Statistics Study under 3-Tesla MRI

  • 1Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
  • 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 3Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea.
  • 4Department of Radiology, Pusan National University Hospital, Busan, Korea.
  • 5School of Biomedical Engineering and u-HARC, Inje University, Gimhae, Korea.
  • 6Department of Health Science & Technology, Inje University, Gimhae, Korea.
  • 7Department of Psychiatry, Medical School, Inje University, Haeundae Paik Hospital, Busan, Korea.


The aim of this study is to determine whether there is any difference in white matter (WM) integrity between Alzheimer's disease (AD) with metabolic syndrome (MetS) and without MetS.
Altogether, 30 subjects were finally recruited from the Memory Impairment Clinics of Pusan National University Hospital in Korea. All subjects (AD with MetS : n=15, matched AD without MetS for age, gender and year of education : n=15) were underwent 3-tesla magnetic resonance imaging scans of diffusion tensor imaging.
The mean fractional anisotropy of the AD with MetS was lower (p<0.05) in right posterior corona radiate, right corticospinal tract and right superior longitudinal fasciculus than that of the AD without MetS.
Our findings suggest that WM integrity damage.


Alzheimer's disease; Metabolic syndrome; White matter integrity; Diffusion tensor imaging
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