Clin Psychopharmacol Neurosci.  2016 Nov;14(4):405-406. 10.9758/cpn.2016.14.4.405.

The Relief Effects of Ramelteon on Refractory Chronic Migraine: A Case Report

  • 1Department of Nutrition, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, ROC.
  • 2Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan, ROC.
  • 3Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.


The selective melatonin receptor agonism effect of ramelteon is useful for insomnia. Here we wanted to present a refractory chronic migraine case, who had significant improvements in migraine after using ramelteon. The possible mechanism for the ramelteon in the migraine relief might be related to melatonin effects.


Ramelteon; Migraine disorders; Sleep wake disorders
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