Clin Psychopharmacol Neurosci.  2016 Nov;14(4):391-395. 10.9758/cpn.2016.14.4.391.

Efficacy of Adenine in the Treatment of Leukopenia and Neutropenia Associated with an Overdose of Antipsychotics or Discontinuation of Lithium Carbonate Administration: Three Case Studies

  • 1Department of Pharmacy, Hospital Bando, Bando, Japan.
  • 2Faculty of Pharmacy, Iwaki Meisei University, Iwaki, Japan.
  • 3Department of Internal Medicine, Hospital Bando, Bando, Japan.
  • 4Department of Psychiatry, Hospital Bando, Bando, Japan.
  • 5Faculty of Health Sciences, Tsukuba International University, Tsuchiura, Japan.


Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell and neutrophil counts. The progress of patients suggests that adenine is effective in cases of leukopenia and neutropenia associated with lithium carbonate discontinuation and an antipsychotic overdose.


Adenine; Leukopenia; Neutropenia; Antipsychotic agents; Lithium carbonate
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