Clin Psychopharmacol Neurosci.  2016 Nov;14(4):378-382. 10.9758/cpn.2016.14.4.378.

Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography

Affiliations
  • 1Department of Psychiatry, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea. vijnana@chol.com
  • 2Department of Nuclear Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.
  • 3Department of Nuclear Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Abstract

The purpose
of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using 18F-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region. The amyloid deposition of the whole brain region was significantly negatively correlated with immediate memory.

Keyword

Amyloid positron emission tomography; Geriatric depression; Alzheimer disease; Subjective memory complaint
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